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If the test indicated a good linkage, the resin was washed once more with DMF, deprotected with 20% piperidine/ DMF for 30 minutes as indicated above, and again washed with DMF

In some embodiments, otic administration of the formulations or compositions described herein avoids toxicity associated with systemic administration (e.g., hepatotoxicity, cardiotoxicity, gastrointestinal side effects, and renal toxicity) of the active agents

Factors that increase side effect risk While AOD 9604 has a favorable safety profile, certain factors can increase the likelihood or severity of unwanted effects

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Limited research has examined the possible side effects of injecting lipotropic agents